Expression and significance of MMP-9 and MDM2 in the oncogenesis of lung cancer in rats

OBJECTIVE@#To observe the expression of matrix metalloproteinase-9 (MMP-9) and mouse double minute 2 homolog (MDM2) in the oncogenesis of lung cancer in rats and to explore their clinical value.@*METHODS@#A total of 140 rats were selected, of which 20 were selected randomly as the control group; and the remaining 120 as the observation group. The observation group was injected with benzopyrene to establish diseases model such as tissue proliferation, abnormal proliferation and lung cancer. Detected the MMP-9 levels of lung tissue by enzyme-linked assay, detected the MDM2 levels of lung tissue by immunochemistry assay.@*RESULTS@#The MMP-9 and MDM2 expression of the lung cancer group and the abnormal proliferation group were significantly higher than that in the tissue proliferation group and the control group, the difference was significant (P0.05). The MDM2 and MMP-9 expression were increased in turn in the small cell carcinoma, squamous cell carcinoma and adenocarcinoma, the difference was statistically significant (P0.05), and there is no significant difference of the MMP-9 and MDM2 expressions between stage I and stage II(P>0.05).@*CONCLUSIONS@#The expression of MMP-9 and MDM2 in lung tissue was associated with lung disease and lung cancer, both of them may be involved in the development and metastasis of lung cancer. Combined detection can be used as therapy and prognostic indicators for lung cancer.

Clinical study of lateral patellofemoral crush syndrome caused by military training / 解放军医学杂志

Objective To explore diagnostic method and surgical outcome of lateral patellofemoral crush syndrome caused by military training. Methods Fifteen patients with lateral patellofemoral crush syndrome caused by military training from May 2006 to May 2008 were enrolled in this study, including 12 men (14 knees) and 3 women (3 knees), aged from 22 to 43 years old with an average of 27.3 years. Randomly selected 18 healthy volunteers with similar age and gender but no knee pain symptom were selected to serve as a control group. Anteroposterior and lateral X-ray photographs of knee joint and axial photographs of the patella were taken in both groups for observing the bone architecture of the knee joint and measuring the femoral trochlear angle, patellofemoral congruence angle and patellofemoral index, and the data were compared. The 17 knee joints in patient group were treated with lateral patellar retinaculum release. Then the preoperative and postoperative pain severity was evaluated with visual analogue scale (VAS). Results Patellofemoral congruence angle was 7.67°± 5.81° and patellofemoral index was 2.49±1.40 in patient group, while they were -2.2°±-2.71° and 1.25±0.15 in control group. The difference between two groups showed statistical significance (P < 0.05). The change in bone architecture was obvious in patient group. The preoperative pain score was 7.06±0.85, and postoperative pain score was 3.87±0.24 after 6 months and 3.01+0.17 after 1 year in patient group. The difference between preoperative pain score and postoperative pain score showed statistical significance (P < 0.05). Conclusions Diagnosis of patellofemoral crush syndrome caused by military training requires a combination of case history, typical symptoms, objective sign and X-ray examination. Among these, X-ray examination is the fundamental auxiliary diagnostic tool for lateral patellofemoral crush syndrome, and the patellofemoral index is convenient for diagnosis.

A clinical study of one-visit endodontic treatment for infected root canals / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To evaluate the post-operative pain level and two years healing of one-visit endodontic treatment for infected root canals.</p><p><b>METHODS</b>76 infected cases were included in one-visit root canal therapy group and 62 infected cases in two-visit group using calcium hydroxide as an interappointment medicament. A comparison of the clinical results was done between the two groups. The main assessments included pre- and post-operative pain evaluated by patients and dentists, and the healing response after six months, one year and two years.</p><p><b>RESULTS</b>There was no statistical significance between the groups regarding pain 7 days after operation and two years' cure rate. After six months, one year and two years, the cure rates of one-visit group were 68.4%, 92.1%, 98.7%, while those of two-visit group were 64.5%, 91.9%, 96.8%, respectively.</p><p><b>CONCLUSION</b>One-visit endodontic treatment for infected root canals has the same clinical efficacy as two-visit in regarding to post-operative pain level and short-term healing.</p>